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Wan A, Xu D, Liu K, Peng L, Cai Y, Chen Y, He Y, Yang J, Jin J, Li H (2017) Efficient expression of stable recombinant human insulin-like growth factor-1 fusion with human serum albumin in Chinese hamster ovary cells
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Importantly, targeting key metabolic pathways, such as PFKFB3-mediated glycolysis, selectively impaired pathological vessel formation without affecting normal vasculature, highlighting the therapeutic potential of metabolic interventions (174)
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These effects have been attributed to inhibition of protein kinase C (PKC) through oxidative stress mechanisms 24,25 , modulation of transforming growth factor- expression 26 and induction of c-myc expression 27
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